In the movie, Rachel made her debut in 2000 - she played a cameo role in the movie "Autumn in New York". Then there were shooting an episode of the fourth season of the series "Sex and the City" (2002). His first major role Nichols performed in comedy movie "Dumb and Dumberer: When Harry Met Lloyd." In 2003, she starred in the independent film "Debating Robert Lee" and in two episodes of the television series "Line of Fire". Rachel Nichols sang supporting roles in the films "The Amityville Horror" (2005), "Dark Forest" (2006), "Resurrecting the Champ" (2007) and "Charlie Wilson's War" (2007).
First star role actress became the heroine of the film "Parking" (2007) - a girl trapped in a underground parking with maniac-guard. Then Rachel starred in the films "The Sisterhood of the Traveling Pants 2" (2008) and "Star Trek" was released in theaters only in 2009. Following its prominent role was Shen O'Hara (Scarlet) - kontrrazvedchitsa and martial arts expert in the action movie "Cobra" (2008). She also played in the film-horror "sale owner" (2009) and heroic fantasy "Conan" (2011).
In July 2008, Nichols was married to producer Scott Stabera, but the marriage lasted only six months. Currently, the actress resides in Los Angeles and often visits his parents in Maine.